Haemodynamic changes and vasopressin release are not consistently associated with carbon dioxide pneumoperitoneum in humans

What Was Tested

Researchers studied Vasopressin in this randomized controlled trial publication.

However, peritoneal stimulations including open surgery cause both a systemic vasopressor response and a vasopressin release, which are suppressed by opiate administration.

Furthermore, previous haemodynamic assessments of laparoscopic surgery have been conducted using various anaesthetic regimens, which are likely to have caused various haemodynamic effects.

Who Took Part

The age groups tagged for this paper are adults, women only.

How the Study Was Run

The researchers set it up as a randomized study.

Random assignment meant chance, not the researchers, decided who got Vasopressin and who got the comparison, which limits bias.

The group receiving 4 ng. ml-1 remifentanil was used as control.

Expired CO2 was maintained within a 32-38 kPa range throughout the investigation.

Complete TEE haemodynamic investigation was performed before pneumoperitoneum (PP) (T1), and during PP horizontal (T2), with a head-up tilt (T3), with a head-down tilt (T4), horizontal (T5), and PP released (T6).

Plasma vasopressin, epinephrine and norepinephrine levels were measured at T1, T3, and T6.

ANOVA, Student's t-test and Mann-Whitney U-test were used for statistical analysis.

What Was Measured

Furthermore, previous haemodynamic assessments of laparoscopic surgery have been conducted using various anaesthetic regimens, which are likely to have caused various haemodynamic effects.

The researchers hypothesised that intraoperative haemodynamic and/or humoral changes would not be observed in association with laparoscopic surgery provided that, (a) normovolaemia is continuously maintained using transoesophageal echocardiographic (TEE) assessment, and (b) adequate depth of general anaesthesia is continuously maintained by bispectral index (BIS) monitoring and high plasma Ievel opiate administration.

The subject headings attached to it are Analgesics, Opioid, Anesthesia, General, Carbon Dioxide, Echocardiography, Transesophageal, Electroencephalography, Epinephrine and Hemodynamics.

What This Means in Plain Language

The paper is a randomized study of Vasopressin.

Its findings take up roughly 2 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2001 (Acta anaesthesiologica Scandinavica), a journal based in England.

More context: the Vasopressin compound page, all human trials.