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Propofol-containing sedatives increase levels of parathyroid hormone
Plain-language guide to PMID 11310903 (2000): double-blind randomized controlled trial study of Parathyroid Hormone (PTH 1-84) in 50 subjects.
Key Facts
- PMID
- 11310903
- Journal
- Intensive care medicine
- Year
- 2000
- Study type
- Randomized Controlled Trial
- Authors
- Zaloga GP et al. (3 authors)
- DOI
- 10.1007/pl00003784
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Parathyroid Hormone (PTH 1-84), published as a randomized controlled trial.
To evaluate the effects of propofol and propofol containing disodium edetate (ethylenediaminetetraacetic acid [EDTA]) on the parathyroid-calcium axis in normal subjects.
Who Took Part
The abstract describes 50 subjects taking part.
By PubMed's age tags, the people studied were adults, middle-aged adults and older adults, both men and women.
A total of 50 healthy subjects.
Each subject was randomised to receive propofol or propofol containing EDTA on day 1 and the alternate treatment between days 15 and 29, with a 2-week wash-out period in between.
How the Study Was Run
The design is described as randomized, double-blind and crossover.
Because people in this Parathyroid Hormone (PTH 1-84) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
As a double-blind Parathyroid Hormone (PTH 1-84) study, the assignments were hidden from both participants and investigators until the end.
Each person switched between Parathyroid Hormone (PTH 1-84) and the comparison at some point, usually with a gap in between.
Randomised, double-blind, age-stratified, crossover trial.
Subjects were monitored for an additional 60 minutes following the infusion.
What Was Measured
Topics PubMed links to this paper include Anesthetics, Intravenous, Calcium, Chelating Agents, Edetic Acid, Magnesium, Parathyroid Hormone and Propofol.
What This Means in Plain Language
The paper is a randomized, double-blind and crossover study of Parathyroid Hormone (PTH 1-84) in 50 subjects.
Its findings take up roughly 9 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.
The publication is from 2000 (Intensive care medicine), a journal based in United States.
More context: the Parathyroid Hormone (PTH 1-84) compound page, all human trials.
Our Notes on the Compound
Parathyroid Hormone (PTH 1-84): The 84-amino-acid hormone that raises blood calcium; full-length PTH (Natpara) has been used in hypoparathyroidism. Teriparatide is its 1-34 fragment.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.