Effect of propofol with and without EDTA on haemodynamics and calcium and magnesium homeostasis during and after cardiac surgery.

What Was Tested

The paper reports a study of Propofol, published as a randomized controlled trial.

To determine the effect of the addition of disodium edetate (EDTA) to propofol on haemodynamics, ionised calcium and magnesium serum concentrations, and adverse events during cardiac surgery.

Who Took Part

According to the abstract, 102 patients were involved.

By PubMed's age tags, the people studied were adults, middle-aged adults and older adults, both men and women.

A total of 102 evaluable patients, aged 34 to 85 years, undergoing first-time, elective coronary artery bypass graft surgery.

How the Study Was Run

In design terms this was a randomized, double-blind and multicenter study.

Because people in this Propofol study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Blinding on both sides kept the patients and researchers unaware of who received Propofol.

Running at several centres spread the Propofol study over different clinics and patient groups.

Operating room and intensive care unit of 5 academic health centres.

Comparison of propofol with EDTA and propofol without EDTA, each in conjunction with the opioid sufentanil, for intraoperative anaesthesia and postoperative sedation.

What Was Measured

The subject headings attached to it are Analysis of Variance, Anesthetics, Intravenous, Calcium, Cardiac Surgical Procedures, Chelating Agents, Edetic Acid and Hemodynamics.

What This Means in Plain Language

The paper is a randomized, double-blind and multicenter study of Propofol in 102 patients.

Its findings take up roughly 6 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2000 (Intensive care medicine), a journal based in United States.

More context: all human trials.