Motilin- and neuropeptide Y-like immunoreactivity in a psychophysiological stress experiment on patients with functional dyspepsia

What Was Tested

The paper reports a study of Neuropeptide Y, published as a clinical trial.

The aim of the study was to compare plasma motilin-like immunoreactivity (MOT-LI) and neuropeptide Y (NPY)-like immunoreactivity (NPY-LI) in patients with functional dyspepsia (FD) during a controlled psychophysiological experiment.

The aim of the interview was to elicit anxiety.

Who Took Part

According to the abstract, 25 patients were involved.

By PubMed's age tags, the people studied were adults and middle-aged adults, both men and women.

Outcome measures were the Gastrointestinal Symptom Rating Scale, fasting blood glucose, heart rate and blood pressure as well as the subjects' self-ratings on visual analogue scales.

How the Study Was Run

Before and during the intervention blood samples were drawn for peptide analyses.

The plasma concentrations of MOT-LI and NPY-LI are given as anti-logarithms.

What Was Measured

PubMed files the paper under topics including Antibodies, Bacterial, Blood Pressure, Dyspepsia, Enzyme-Linked Immunosorbent Assay, Heart Rate, Helicobacter pylori and Motilin.

What This Means in Plain Language

This is a clinical trial of Neuropeptide Y in 25 patients.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The abstract goes on to report its results in about 6 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2000 (Integrative physiological and behavioral science : the official journal of the Pavlovian Society), a journal based in United States.

More context: the Neuropeptide Y compound page, all human trials.