Cerebral blood flow velocity response to magnesium sulfate in patients after subarachnoid hemorrhage.

What Was Tested

Researchers studied Magnesium Sulfate in this randomized controlled trial publication.

Fourteen patients (11 women, 3 men; mean age 58 years) underwent 29 studies.

All patients underwent hypertensive, hypervolemic therapy.

Who Took Part

The abstract describes 11 women taking part.

PubMed indexes the participants as adults, middle-aged adults, older adults and people over 80, both men and women.

How the Study Was Run

In design terms this was a randomized, double-blind and placebo-controlled study.

Because people in this Magnesium Sulfate study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Blinding on both sides kept the women and researchers unaware of who received Magnesium Sulfate.

The comparison arm used a placebo, so changes seen with Magnesium Sulfate could be set against what happens without it.

Transcranial Doppler ultrasonography of the middle cerebral artery (MCA) was measured after each infusion.

What Was Measured

The subject headings attached to it are Anticonvulsants, Blood Flow Velocity, Blood Pressure, Cerebrovascular Circulation, Intracranial Aneurysm, Magnesium Sulfate and Middle Cerebral Artery.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Magnesium Sulfate in 11 women.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The publication is from 2001 (Journal of neurosurgical anesthesiology), a journal based in United States.

More context: all human trials.