Population pharmacokinetic-pharmacodynamic model of craving in an enforced smoking cessation population: indirect response and probabilistic modeling.

What Was Tested

Researchers studied Nicotine in this randomized controlled trial publication.

The study objective was to describe the nicotine-induced changes on craving scores.

Who Took Part

By PubMed's age tags, the people studied were adults and middle-aged adults, both men and women.

Twenty-four smokers were enrolled in a placebo-controlled, randomized, double-blind, three periods, crossover trial.

How the Study Was Run

The researchers set it up as a randomized, double-blind, placebo-controlled and crossover study.

The participants were allocated by chance, so the Nicotine group and the comparison group should start out alike.

As a double-blind Nicotine study, the assignments were hidden from both participants and investigators until the end.

The comparison arm used a placebo, so changes seen with Nicotine could be set against what happens without it.

Each person switched between Nicotine and the comparison at some point, usually with a gap in between.

Two modeling strategies based on a mechanistic (indirect response models with drug-related inhibition on the k(in) synthesis rate and with a drug-related stimulation of the k(out) removal rate were evaluated) and a probabilistic (logistic regression) approach were used.

What Was Measured

The subject headings attached to it are Behavior, Addictive, Logistic Models, Models, Psychological, Models, Statistical, Nicotine, Nicotinic Agonists and Saliva.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Nicotine.

Its findings take up roughly 4 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2001 (Pharmaceutical research), a journal based in United States.

More context: the related Therapeutic nicotine (patch, non-peptide) library page, all human trials.