GH administration and discontinuation in healthy elderly men: effects on body composition, GH-related serum markers, resting heart rate and resting oxygen uptake.

What Was Tested

The paper reports a study of Human Growth Hormone, published as a randomized controlled trial.

Several studies have focused on effects of GH administration in the elderly in the last decade.

However, very limited information is available regarding changes in body composition and EE upon GH discontinuation in the elderly.

The present study therefore investigated the effects of 12 weeks of GH administration and subsequent discontinuation on body composition, resting oxygen uptake (VO2), resting heart rate (HR) and GH related serum markers in healthy elderly men.

Who Took Part

PubMed indexes the participants as older adults and people over 80, men only.

How the Study Was Run

The researchers set it up as a randomized, single-blind and placebo-controlled study.

Because people in this Human Growth Hormone study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

In this single-blind Human Growth Hormone study one party knew the assignments and the other did not.

The comparison arm used a placebo, so changes seen with Human Growth Hormone could be set against what happens without it.

What Was Measured

The subject headings attached to it are Biomarkers, Body Composition, Calorimetry, Indirect, Carrier Proteins, Energy Metabolism, Glycoproteins and Heart Rate.

What This Means in Plain Language

The paper is a randomized, single-blind and placebo-controlled study of Human Growth Hormone.

The abstract goes on to report its results in about 10 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2001 (Clinical endocrinology), a journal based in England.

More context: the related Exogenous HGH, sermorelin & older GHRPs (why they're passed over) library page, all human trials.