Estrogen and progesterone effects on transcapillary fluid dynamics.

What Was Tested

This randomized controlled trial looks at Leuprolide and Progesterone.

The purpose of this study was to determine estrogen (E(2)) and progesterone (P(4)) effects on atrial natriuretic peptide (ANP) control of plasma volume (PV) and transcapillary fluid dynamics.

Why It Was Studied

At the end of the 4th and 5th week of GnRH analog and hormone administration, the researchers determined PV (Evans blue dye) and changes in PV and forearm capillary filtration coefficient (CFC) during a 120-min infusion of ANP (5 ng x kg body wt(-1) x min(-1)).

Preinfusion PV was estimated from Evans blue dye measurement taken over the last 30 min of infusion based on changes in hematocrit.

Who Took Part

The abstract describes 12 women taking part.

PubMed indexes the participants as adults, women only.

How the Study Was Run

The design is described as randomized.

Because people in this Leuprolide study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

What Was Measured

Preinfusion PV was estimated from Evans blue dye measurement taken over the last 30 min of infusion based on changes in hematocrit.

Topics PubMed links to this paper include Atrial Natriuretic Factor, Blood Pressure, Blood Volume, Capillaries, Capillary Permeability, Cardiac Output and Drug Administration Routes.

What This Means in Plain Language

The paper is a randomized study of Leuprolide and Progesterone in 12 women.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The publication is from 2001 (American journal of physiology. Regulatory, integrative and comparative physiology), a journal based in United States.

More context: the related Leuprolide library page, all human trials.