The effects of angiotensin II on pulse wave velocity in healthy humans

What Was Tested

Researchers studied Angiotensin II in this randomized controlled trial publication.

Who Took Part

The study group was 9 volunteers.

The age groups tagged for this paper are adults, men only.

How the Study Was Run

In design terms this was a randomized, double-blind, placebo-controlled and crossover study.

The volunteers were allocated by chance, so the Angiotensin II group and the comparison group should start out alike.

Neither the volunteers nor the staff measuring them knew who was on Angiotensin II, so expectations could not easily colour the readings.

The comparison arm used a placebo, so changes seen with Angiotensin II could be set against what happens without it.

Each person switched between Angiotensin II and the comparison at some point, usually with a gap in between.

The researchers measured carotid-femoral PWV using a novel device complior.

Heart rate, blood pressure and PWV were recorded at baseline and then every 10 minutes during the infusion and twice after the end of the infusion.

What Was Measured

Topics PubMed links to this paper include Analysis of Variance, Angiotensin II, Hemodynamics and Vasoconstrictor Agents.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Angiotensin II in 9 volunteers.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The abstract goes on to report its results in about 6 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2001 (International journal of clinical pharmacology and therapeutics), a journal based in Germany.

More context: the Angiotensin II compound page, all human trials.