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Psychological assessments before and after treatment of early puberty in adopted children.
Plain-language guide to PMID 11683207 (2001): randomized controlled trial of Human Growth Hormone and Gonadotropin-Releasing Hormone in 30 children.
Key Facts
- PMID
- 11683207
- Journal
- Acta paediatrica (Oslo, Norway : 1992)
- Year
- 2001
- Study type
- Randomized Controlled Trial
- Authors
- Mul D et al. (6 authors)
- DOI
- 10.1080/080352501316978011
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial looks at Human Growth Hormone and Gonadotropin-Releasing Hormone.
Early puberty is frequently observed in adopted children.
This randomized trial treated 30 adopted children with early puberty and short stature with either gonadotropin-releasing hormone agonist (GnRHa) alone or in combination with growth hormone (GH) for 3 y.
Who Took Part
The study group was 30 children.
The age groups tagged for this paper are infants, young children and children, both men and women.
How the Study Was Run
The researchers set it up as a randomized study.
Because people in this Human Growth Hormone study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
What Was Measured
Before the start of treatment (T1) in the trial and at discontinuation (T2) the children and their parents underwent a psychological evaluation.
The findings are discussed with reference to the reported levels of behavioural and emotional problems in adopted children and the psychosocial effects of precocious puberty.
PubMed files the paper under topics including Adoption, Body Height, Gonadotropin-Releasing Hormone, Human Growth Hormone, Intelligence Tests, Interview, Psychological and Puberty, Precocious.
What This Means in Plain Language
The paper is a randomized study of Human Growth Hormone and Gonadotropin-Releasing Hormone in 30 children.
With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.
The abstract goes on to report its results in about 2 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 2001 (Acta paediatrica (Oslo, Norway : 1992)), a journal based in Norway.
More context: the related Exogenous HGH, sermorelin & older GHRPs (why they're passed over) library page, all human trials.
Related Library Page
Exogenous HGH, sermorelin & older GHRPs (why they're passed over): Constant levels suppress the body's own GHRH, raise somatostatin and dull pituitary response.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.