Insulin lispro lowers postprandial glucose in prepubertal children with diabetes

What Was Tested

The paper reports a study of Insulin Lispro, published as a randomized controlled trial.

This study compared the glucose-lowering effect of insulin lispro, given before or after meals, with regular human insulin given before meals in prepubertal children with diabetes.

Who Took Part

According to the abstract, 61 children were involved.

By PubMed's age tags, the people studied were young children and children, both men and women.

A 3-way crossover, open-label study involving 61 prepubertal children (ages 2.9-11.4 years) with type 1 diabetes.

The children were randomly assigned to receive regular human insulin 30 to 45 minutes before meals, insulin lispro within 15 minutes before or immediately after meals, combined with basal insulin.

How the Study Was Run

The researchers set it up as a randomized, open-label and crossover study.

Because people in this Insulin Lispro study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Being open-label, the Insulin Lispro study did not mask who received what.

In the crossover set-up each of the children took both Insulin Lispro and the comparison in turn, acting as their own control.

Each treatment lasted 3 months.

Hemoglobin A(1c) levels and home glucose monitoring profiles were measured at the end of each treatment period.

What Was Measured

The subject headings attached to it are Age Factors, Analysis of Variance, Blood Glucose, Diabetes Mellitus, Type 1, Hemoglobin A, Hypoglycemic Agents and Insulin.

What This Means in Plain Language

The paper is a randomized, open-label and crossover study of Insulin Lispro in 61 children.

Its findings take up roughly 5 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2001 (Pediatrics), a journal based in United States.

More context: the Insulin Lispro compound page, all human trials.