The effect of desmopressin on short-term memory in children with primary nocturnal enuresis

What Was Tested

This randomized controlled trial paper looks at Vasopressin and Desmopressin.

The use of desmopressin in patients with primary nocturnal enuresis is based on the hypothesis of a nocturnal lack of endogenous arginine vasopressin.

However, in addition to the kidney, other targets of desmopressin are known.

Therefore, the researchers examined whether the administration of desmopressin influences central nervous function in children with primary nocturnal enuresis.

Who Took Part

The abstract describes 40 children taking part.

The age groups tagged for this paper are children and teenagers, both men and women.

Their prospective, randomized, double-blind, placebo controlled cross-over study was performed on 40 children with nocturnal enuresis.

Each group comprised 19 and 21 to children, respectively.

How the Study Was Run

In design terms this was a randomized, double-blind, placebo-controlled and crossover study.

Because people in this Vasopressin study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

As a double-blind Vasopressin study, the assignments were hidden from both participants and investigators until the end.

Some children received a placebo instead of Vasopressin, giving a reference point.

In the crossover set-up each of the children took both Vasopressin and the comparison in turn, acting as their own control.

The methods mention a period of 2 weeks.

After 2 weeks the groups were switched.

The children were tested for short-term memory and reaction time to both treatments.

Statistical analysis was done using the Wilcoxon matched pairs test.

What Was Measured

PubMed files the paper under topics including Deamino Arginine Vasopressin, Enuresis, Memory, Short-Term and Renal Agents.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Vasopressin and Desmopressin in 40 children over 2 weeks.

Its findings take up roughly 5 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2001 (The Journal of urology), a journal based in United States.

More context: the Vasopressin compound page and the Desmopressin compound page, all human trials.