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Zinc supplementation increases bone alkaline phosphatase in healthy men.
Plain-language guide to PMID 11787985 (2001): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 20 volunteers.
Key Facts
- PMID
- 11787985
- Journal
- Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)
- Year
- 2001
- Study type
- Randomized Controlled Trial
- Authors
- Peretz A et al. (8 authors)
- DOI
- 10.1016/S0946-672X(01)80063-8
What This Study Did, in Plain Language
What Was Tested
Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.
To investigate bone turnover, total alkaline phosphatases activity (ALP), bone specific alkaline phosphatase activity (BAPE) and BAP mass (BAP-M) concentration were measured as parameters of bone formation while urine calcium and C-terminal collagen peptide were determined as parameters of bone resorption.
Why It Was Studied
Zinc takes part in the metabolism of bone as a constituent of the matrix and as an activator of several metallo-enzymes.
Samples were obtained in fasting subjects at baseline and after 6 and 12 weeks.
Who Took Part
According to the abstract, 20 volunteers were involved.
The age groups tagged for this paper are adults, men only.
How the Study Was Run
In design terms this was a randomized, double-blind and placebo-controlled study.
Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
Blinding on both sides kept the volunteers and researchers unaware of who received Vitamin D, K2, Magnesium and Zinc.
A placebo (an inactive look-alike) gave the Vitamin D, K2, Magnesium and Zinc group a baseline to be compared against.
What Was Measured
PubMed files the paper under topics including Alkaline Phosphatase, Bone and Bones, Dietary Supplements and Zinc.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 20 volunteers.
With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.
The publication is from 2001 (Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)), a journal based in Germany.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.