[Effect of yimai jiangya extract on platelet activation and fibrinolytic activity and angiotensin II in aged patients with essential hypertension]

What Was Tested

This randomized controlled trial looks at Angiotensin II.

To observe the effect of Yimai Jiangya extract (YMJYE) on platelet alpha-granule membrane protein (GMP-140), tissue-type plasminogen activator (t-PA) and its inhibitor (PAI), angiotensin II (AngII) in aged patients with essential hypertension (EH) of stage 2 caused by Qi deficiency and blood stasis.

Radioimmunoassay (RIA) and colorimetric analysis were used to examine the levels of GMP-140, t-PA, PAI and AngII before and after treatment with YMJYE in 42 aged patients (treated group), compared with that of 30 aged patients before and after treatment with captopril (control group) and 30 aged healthy subjects (healthy group).

Who Took Part

The study group was 42 patients.

PubMed indexes the participants as middle-aged adults and older adults, both men and women.

How the Study Was Run

The researchers set it up as a randomized study.

The patients were allocated by chance, so the Angiotensin II group and the comparison group should start out alike.

What Was Measured

PubMed files the paper under topics including Angiotensin II, Drugs, Chinese Herbal, Fibrinolytic Agents, Hypertension, P-Selectin, Plasminogen Activator Inhibitor 1 and Platelet Aggregation.

What This Means in Plain Language

The paper is a randomized study of Angiotensin II in 42 patients.

The abstract goes on to report its results in about 7 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2000 (Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine), a journal based in China.

More context: the Angiotensin II compound page, all human trials.