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Effects of exogenous corticotropin-releasing factor on antropyloroduodenal motility and appetite in humans
Plain-language guide to PMID 11811169 (2002): double-blind randomized controlled trial study of ACTH (Corticotropin) and CRH (Corticotropin-Releasing Hormone).
Key Facts
- PMID
- 11811169
- Journal
- The American journal of gastroenterology
- Year
- 2002
- Study type
- Randomized Controlled Trial
- Authors
- Su YC et al. (7 authors)
- DOI
- 10.1111/j.1572-0241.2002.05422.x
What This Study Did, in Plain Language
What Was Tested
Researchers studied ACTH (Corticotropin) and CRH (Corticotropin-Releasing Hormone) in this randomized controlled trial publication.
The researchers have evaluated the effects of exogenous CRF on antropyloroduodenal motility and appetite in humans.
Who Took Part
By PubMed's age tags, the people studied were adults, both men and women.
On 2 separate days, six healthy volunteers received, in randomized, double-blind fashion, i.v.
Venous blood was obtained for measurements of serum cortisol and paracetamol.
How the Study Was Run
The design is described as randomized and double-blind.
Because people in this ACTH (Corticotropin) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
Neither the participants nor the staff measuring them knew who was on ACTH (Corticotropin), so expectations could not easily colour the readings.
Antropyloroduodenal pressures were measured with sleeve/sidehole manometry and perceptions of appetite by visual analog scales.
At t = 150 min the manometric catheter was removed and subjects offered a buffet meal (150-180 min).
The amount and macronutrient content of food consumed were quantified.
What Was Measured
Topics PubMed links to this paper include Acetaminophen, Analysis of Variance, Appetite, Corticotropin-Releasing Hormone, Gastrointestinal Motility, Hydrocortisone and Probability.
What This Means in Plain Language
The paper is a randomized and double-blind study of ACTH (Corticotropin) and CRH (Corticotropin-Releasing Hormone).
The abstract goes on to report its results in about 3 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 2002 (The American journal of gastroenterology), a journal based in United States.
More context: the ACTH (Corticotropin) compound page and the CRH (Corticotropin-Releasing Hormone) compound page, all human trials.
Our Notes on the Compounds
ACTH (Corticotropin): The 39-amino-acid pituitary hormone that drives cortisol production; given as repository corticotropin (Acthar Gel).
CRH (Corticotropin-Releasing Hormone): The 41-amino-acid hypothalamic hormone that triggers ACTH release; corticorelin is used diagnostically.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.