GH administration changes myosin heavy chain isoforms in skeletal muscle but does not augment muscle strength or hypertrophy, either alone or combined with resistance exercise training in healthy elderly men.

Plain-language guide to PMID 11836279 (2002): double-blind randomized controlled trial of Growth Hormone.

Key Facts

PMID: 11836279
Journal: The Journal of clinical endocrinology and metabolism
Year: 2002
Study type: Randomized Controlled Trial
Authors: Lange KH et al. (9 authors)
DOI: 10.1210/jcem.87.2.8206

What This Study Did, in Plain Language

What Was Tested

The paper reports a study of Growth Hormone, published as a randomized controlled trial.

GH alone had no effect on isokinetic quadriceps muscle strength, power, CSA, or fiber size.

Who Took Part

The age groups tagged for this paper are older adults and people over 80, men only.

In the present study, 31 healthy, elderly men [age, 74 +/- 1 yr (mean +/- SEM)] were assigned to either RT [3 sessions/wk, 3-5 sets of 8-12 repetition maximum (RM)/session] + placebo (n = 8), RT + GH (n = 8), GH (n = 8), or placebo (n = 7) in a randomized, placebo-controlled, double-blinded (RT + placebo and RT + GH) or single-blinded (GH or placebo) design.

How the Study Was Run

In design terms this was a randomized, double-blind, single-blind and placebo-controlled study.

Because people in this Growth Hormone study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

As a double-blind Growth Hormone study, the assignments were hidden from both participants and investigators until the end.

Only one side, usually the participants, was kept unaware of whether Growth Hormone was given.

The comparison arm used a placebo, so changes seen with Growth Hormone could be set against what happens without it.

What Was Measured

The subject headings attached to it are Absorptiometry, Photon, Blood, Growth Hormone, Hypertrophy, Magnetic Resonance Spectroscopy, Muscle Contraction and Muscle Fibers, Skeletal.

What This Means in Plain Language

The paper is a randomized, double-blind and single-blind study of Growth Hormone.

The publication is from 2002 (The Journal of clinical endocrinology and metabolism), a journal based in United States.

More context: the related Exogenous HGH, sermorelin & older GHRPs (why they're passed over) library page, all human trials.

Related Library Page

Exogenous HGH, sermorelin & older GHRPs (why they're passed over): Constant levels suppress the body's own GHRH, raise somatostatin and dull pituitary response.

Exogenous HGH, sermorelin & older GHRPs (why they're passed over) in the library

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.