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Urethritis associated with Chlamydia trachomatis: comparison of leukocyte esterase dipstick test of first-voided urine and methylene blue-stained urethral smear as predictors of chlamydial infection
Plain-language guide to PMID 11878712 (2001): clinical trial study of Methylene blue (non-peptide stack partner) in 480 patients.
Key Facts
- PMID
- 11878712
- Journal
- APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
- Year
- 2001
- Study type
- Clinical Trial
- Authors
- Hedin G et al. (3 authors)
- DOI
- 10.1034/j.1600-0463.2001.d01-180.x
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Methylene blue (non-peptide stack partner), published as a clinical trial.
The aim of this study was to compare the performance of two alternative tests in the diagnosis of urethritis as predictors of C. trachomatis infection: the leukocyte esterase (LE) dipstick test of first-voided urine and polymorphonuclear leukocyte counts in a methylene blue-stained (MBS) urethral smear.
Why It Was Studied
The use of nucleic acid amplification tests for the diagnosis of C. trachomatis has made it possible to send urine samples instead of urethral swab specimens to the laboratory.
Urine samples from 480 male patients attending an STD clinic were analysed using the LE test and LCR assay for C. trachomatis; urethral samples were analysed with MBS urethral smear and LCR.
Who Took Part
The study group was 480 patients.
By PubMed's age tags, the people studied were teenagers and adults, men only.
What Was Measured
The use of nucleic acid amplification tests for the diagnosis of C. trachomatis has made it possible to send urine samples instead of urethral swab specimens to the laboratory.
Urine samples from 480 male patients attending an STD clinic were analysed using the LE test and LCR assay for C. trachomatis; urethral samples were analysed with MBS urethral smear and LCR.
PubMed files the paper under topics including Carboxylic Ester Hydrolases, Chlamydia Infections, Chlamydia trachomatis, Methylene Blue, Neutrophils, Predictive Value of Tests and Reagent Strips.
What This Means in Plain Language
This is a clinical trial of Methylene blue (non-peptide stack partner) in 480 patients.
With several hundred people or more, it is a fairly large study for this kind of research.
The publication is from 2001 (APMIS : acta pathologica, microbiologica, et immunologica Scandinavica), a journal based in Denmark.
More context: the Methylene blue (non-peptide stack partner) compound page, all human trials.
Our Notes on the Compound
Methylene blue (non-peptide stack partner): Described as an electron cycler, not just a dye.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.