The effects of cimetidine and antacid on the pharmacokinetic profile of sildenafil citrate in healthy male volunteers.

What Was Tested

The paper reports a study of Cimetidine and Magnesium Hydroxide, published as a randomized controlled trial.

Blood samples were collected predose and at specified times up to 48 h postdose on days 1 and 5 to determine plasma levels of sildenafil and its metabolite, UK-103,320.

Who Took Part

According to the abstract, 22 volunteers were involved.

By PubMed's age tags, the people studied were adults and middle-aged adults, men only.

How the Study Was Run

The researchers set it up as a randomized, open-label, placebo-controlled, crossover and parallel-group study.

The volunteers were allocated by chance, so the Cimetidine group and the comparison group should start out alike.

Being open-label, the Cimetidine study did not mask who received what.

Some volunteers received a placebo instead of Cimetidine, giving a reference point.

Each person switched between Cimetidine and the comparison at some point, usually with a gap in between.

Blood samples were collected and analysed as in the first study.

The two study periods were separated by at least 14 days.

What Was Measured

PubMed files the paper under topics including Aluminum Hydroxide, Antacids, Anti-Ulcer Agents, Area Under Curve, Cimetidine, Drug Combinations and Half-Life.

What This Means in Plain Language

The paper is a randomized, open-label and placebo-controlled study of Cimetidine and Magnesium Hydroxide in 22 volunteers.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

Its findings take up roughly 7 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2002 (British journal of clinical pharmacology), a journal based in England.

More context: all human trials.