Enhanced responses of blood pressure, renal function, and aldosterone to angiotensin I in the DD genotype are blunted by low sodium intake

What Was Tested

This randomized controlled trial paper looks at Angiotensin II in the context of low blood pressure and orthostatic hypotension.

Blunted responses of BP and proteinuria to ACE inhibition among DD renal patients during periods of high sodium intake were reported.

It was therefore hypothesized that sodium status affects the phenotype in the ACE I/D polymorphism.

Who Took Part

According to the abstract, 27 subjects were involved.

The age groups tagged for this paper are adults, both men and women.

How the Study Was Run

The design is described as randomized.

Because people in this Angiotensin II study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

What Was Measured

Baseline mean arterial pressure (MAP) values, renal hemodynamic parameters, and renin-angiotensin system parameters were similar for all genotypes with either sodium intake level.

Topics PubMed links to this paper include Aldosterone, Angiotensin I, Angiotensin II, Blood Pressure, Diet, Sodium-Restricted, Genotype and Glomerular Filtration Rate.

What This Means in Plain Language

The paper is a randomized study of Angiotensin II in 27 subjects in people with low blood pressure and orthostatic hypotension.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The publication is from 2002 (Journal of the American Society of Nephrology : JASN), a journal based in United States.

More context: the Angiotensin II compound page, Low blood pressure and orthostatic hypotension research.