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Prolactin and growth hormone secretion after thyrotrophin-releasing hormone infusion and dopaminergic (DA2) blockade in infertile patients with minimal/mild endometriosis
Plain-language guide to PMID 11925390 (2002): randomized controlled trial study of TRH (Thyrotropin-Releasing Hormone) in 64 women, endometriosis.
Key Facts
- PMID
- 11925390
- Journal
- Human reproduction (Oxford, England)
- Year
- 2002
- Study type
- Randomized Controlled Trial
- Authors
- Cunha-Filho JS et al. (7 authors)
- DOI
- 10.1093/humrep/17.4.960
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of TRH (Thyrotropin-Releasing Hormone) in the context of endometriosis, published as a randomized controlled trial.
This study aimed to evaluate PRL and GH secretion after metoclopramide and thyrotrophin-releasing hormone (TRH) infusion in infertile patients with minimal/mild endometriosis.
Why It Was Studied
The origin of infertility in patients with endometriosis without tubal occlusion has not yet been clearly defined.
Several reports show an abnormal pituitary-ovarian axis in this group of patients.
Who Took Part
According to the abstract, 64 women were involved.
PubMed tags the participants as women only.
A total of 64 women participated in the study: 33 fertile patients without endometriosis; 10 fertile patients with minimal/mild endometriosis; and 21 infertile patients with minimal/mild endometriosis.
TRH or metoclopramide was administered randomly in two sequential menstrual cycles (cycle days 3-5).
How the Study Was Run
In design terms this was a randomized study.
Random assignment meant chance, not the researchers, decided who got TRH (Thyrotropin-Releasing Hormone) and who got the comparison, which limits bias.
Serum PRL and GH secretion before and after dopaminergic type 2 (DA2) receptor blockade and TRH were compared.
What Was Measured
Topics PubMed links to this paper include Case-Control Studies, Dopamine Antagonists, Dopamine D2 Receptor Antagonists, Endometriosis, Estradiol, Human Growth Hormone and Infertility, Female.
What This Means in Plain Language
The paper is a randomized study of TRH (Thyrotropin-Releasing Hormone) in 64 women in people with endometriosis.
Its findings take up roughly 4 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.
The publication is from 2002 (Human reproduction (Oxford, England)), a journal based in England.
More context: the TRH (Thyrotropin-Releasing Hormone) compound page, Endometriosis research.
Our Notes on the Compound
TRH (Thyrotropin-Releasing Hormone): A 3-amino-acid hypothalamic hormone (protirelin) that triggers TSH and prolactin release.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.