Effects of budesonide inhalation suspension on hypothalamic-pituitary-adrenal-axis function in infants and young children with persistent asthma.

What Was Tested

Researchers studied Adrenocorticotropic Hormone and Budesonide in this randomized controlled trial publication.

Complete results of the earlier phases of the studies and of long-term safety are reported elsewhere; only results pertaining to HPA-axis function are summarized here.

Who Took Part

The age groups tagged for this paper are infants, young children and children, both men and women.

Patients eligible for the open-label phases of the three trials were randomized to treatment with nebulized BIS (n = 447) or CAT (n = 223).

How the Study Was Run

The design is described as randomized, double-blind and open-label.

Because people in this Adrenocorticotropic Hormone study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Blinding on both sides kept the participants and researchers unaware of who received Adrenocorticotropic Hormone.

Everyone knew when Adrenocorticotropic Hormone was being given (open label), which is simpler to run but leaves more room for expectations to affect what is reported.

CAT included short-acting oral or inhaled beta2-agonists, methylxanthines, or cromolyn sodium; in two of the studies, CAT could have included other inhaled corticosteroids.

What Was Measured

The subject headings attached to it are Administration, Inhalation, Adrenocorticotropic Hormone, Anti-Inflammatory Agents, Asthma, Budesonide, Hypothalamo-Hypophyseal System and Pituitary-Adrenal System.

What This Means in Plain Language

The paper is a randomized, double-blind and open-label study of Adrenocorticotropic Hormone and Budesonide.

The abstract goes on to report its results in about 3 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2002 (Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology), a journal based in United States.

More context: the related ACTH (Corticotropin) library page, all human trials.