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CGRP may play a causative role in migraine
Plain-language guide to PMID 11993614 (2002): double-blind randomized controlled trial study of CGRP (Calcitonin Gene-Related Peptide) in 12 patients, migraine.
Key Facts
- PMID
- 11993614
- Journal
- Cephalalgia : an international journal of headache
- Year
- 2002
- Study type
- Randomized Controlled Trial
- Authors
- Lassen LH et al. (6 authors)
- DOI
- 10.1046/j.1468-2982.2002.00310.x
What This Study Did, in Plain Language
What Was Tested
Researchers studied CGRP (Calcitonin Gene-Related Peptide) in the context of migraine in this randomized controlled trial publication.
However, it is unknown whether this is secondary to migraine or whether CGRP may cause headache.
Headache intensity was scored on a scale from 0 to 10.
Who Took Part
The study group was 12 patients.
The age groups tagged for this paper are adults and middle-aged adults, both men and women.
How the Study Was Run
The researchers set it up as a randomized, double-blind, placebo-controlled and crossover study.
Because people in this CGRP (Calcitonin Gene-Related Peptide) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
Blinding on both sides kept the patients and researchers unaware of who received CGRP (Calcitonin Gene-Related Peptide).
A placebo (an inactive look-alike) gave the CGRP (Calcitonin Gene-Related Peptide) group a baseline to be compared against.
In the crossover set-up each of the patients took both CGRP (Calcitonin Gene-Related Peptide) and the comparison in turn, acting as their own control.
What Was Measured
However, it is unknown whether this is secondary to migraine or whether CGRP may cause headache.
Headache intensity was scored on a scale from 0 to 10.
PubMed files the paper under topics including Blood Flow Velocity, Brain, Calcitonin Gene-Related Peptide, Middle Cerebral Artery, Migraine Disorders, Regional Blood Flow and Tomography, Emission-Computed, Single-Photon.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of CGRP (Calcitonin Gene-Related Peptide) in 12 patients in people with migraine.
With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.
The publication is from 2002 (Cephalalgia : an international journal of headache), a journal based in England.
More context: the CGRP (Calcitonin Gene-Related Peptide) compound page, Migraine research.
Our Notes on the Compound
CGRP (Calcitonin Gene-Related Peptide): A 37-amino-acid neuropeptide that widens blood vessels and is involved in migraine; given in research provocation studies.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.