Impact of prior nicotine replacement therapy on smoking cessation efficacy.

What Was Tested

The paper reports a study of Therapeutic nicotine (patch, non-peptide), published as a randomized controlled trial.

Who Took Part

By PubMed's age tags, the people studied were adults and middle-aged adults, both men and women.

How the Study Was Run

The researchers set it up as a randomized, double-blind, placebo-controlled and parallel-group study.

Because people in this Therapeutic nicotine (patch, non-peptide) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Neither the participants nor the staff measuring them knew who was on Therapeutic nicotine (patch, non-peptide), so expectations could not easily colour the readings.

The comparison arm used a placebo, so changes seen with Therapeutic nicotine (patch, non-peptide) could be set against what happens without it.

The Therapeutic nicotine (patch, non-peptide) group and the comparison group ran side by side rather than switching.

Secondary analysis of a parallel-group, randomized, double-blind, placebo-controlled study.

Smokers who had, based on self-report, no previous history of NRT (N = 453) or who had used NRT at least once (N = 440) were randomized to receive placebo, bupropion SR, nicotine transdermal system (NTS), or a combination of bupropion SR and NTS.

What Was Measured

Topics PubMed links to this paper include Administration, Cutaneous, Antidepressive Agents, Second-Generation, Likelihood Functions, Nicotine, Smoking Cessation, Tobacco Use Disorder and United States.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Therapeutic nicotine (patch, non-peptide).

Results are reported in around 2 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2002 (American journal of health behavior), a journal based in England.

More context: the Therapeutic nicotine (patch, non-peptide) compound page, all human trials.