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Randomized trial of methylcobalamin and folate effects on homocysteine in hemodialysis patients
Plain-language guide to PMID 12021520 (2002): double-blind randomized controlled trial of Cyanocobalamin (Vitamin B12) in 62 patients.
Key Facts
- PMID
- 12021520
- Journal
- Nephron
- Year
- 2002
- Study type
- Randomized Controlled Trial
- Authors
- Trimarchi H et al. (4 authors)
- DOI
- 10.1159/000057605
What This Study Did, in Plain Language
What Was Tested
Researchers studied Cyanocobalamin (Vitamin B12) in this randomized controlled trial publication.
There are no data available on the effects of intravenous (i.v.) methylcobalamin (Me-Cbl), the coenzymatically active form of vitamin B12 that acts as a cofactor for methionine synthase in the conversion of total homocysteine (tHcy) to methionine, with or without oral folic acid (FA) supplementation, on fasting tHcy levels in hemodialysis (HD) patients.
Who Took Part
The abstract describes 62 patients taking part.
By PubMed's age tags, the people studied were adults, middle-aged adults, older adults and people over 80, both men and women.
The researchers performed a prospective randomized trial in which 62 chronic HD patients without previous vitamin supplementation were divided into four groups.
How the Study Was Run
The design is described as randomized and double-blind.
Because people in this Cyanocobalamin (Vitamin B12) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
As a double-blind Cyanocobalamin (Vitamin B12) study, the assignments were hidden from both participants and investigators until the end.
What Was Measured
There are no data available on the effects of intravenous (i.v.) methylcobalamin (Me-Cbl), the coenzymatically active form of vitamin B12 that acts as a cofactor for methionine synthase in the conversion of total homocysteine (tHcy) to methionine, with or without oral folic acid (FA) supplementation, on fasting tHcy levels in hemodialysis (HD) patients.
Topics PubMed links to this paper include Folic Acid, Homocysteine, Methylation, Renal Dialysis and Vitamin B 12.
What This Means in Plain Language
The paper is a randomized and double-blind study of Cyanocobalamin (Vitamin B12) in 62 patients.
The abstract goes on to report its results in about 5 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 2002 (Nephron), a journal based in Switzerland.
More context: the Cyanocobalamin (Vitamin B12) compound page, all human trials.
Our Notes on the Compound
Cyanocobalamin (Vitamin B12): A synthetic form of vitamin B12 (cobalamin), an essential nutrient for DNA synthesis, red blood cell formation and neurological function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.