Evaluation of high concentration intranasal and intravenous desmopressin in pediatric patients with mild hemophilia A or mild-to-moderate type 1 von Willebrand disease

What Was Tested

This clinical trial paper looks at Vasopressin and Desmopressin.

Who Took Part

According to the abstract, 8 girls were involved.

The age groups tagged for this paper are infants, young children, children and teenagers, both men and women.

HCIN-DDAVP responses were compared with historic IV-DDAVP responses in 13 of the patients.

How the Study Was Run

In design terms this was an open-label study.

Everyone knew when Vasopressin was being given (open label), which is simpler to run but leaves more room for expectations to affect what is reported.

Nine boys with hemophilia A, 8 girls with mild VWD, and 8 boys with mild VWD were evaluated.

What Was Measured

PubMed files the paper under topics including Analysis of Variance, Deamino Arginine Vasopressin, Hemophilia A, Hemostatics and von Willebrand Diseases.

What This Means in Plain Language

The paper is an open-label study of Vasopressin and Desmopressin in 8 girls.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

Its findings take up roughly 6 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2002 (The Journal of pediatrics), a journal based in United States.

More context: the Vasopressin compound page and the Desmopressin compound page, all human trials.