Comment: the corticotropin-releasing hormone stimulation test in white coat hypertension

What Was Tested

Researchers studied ACTH (Corticotropin) and CRH (Corticotropin-Releasing Hormone) in this controlled clinical trial publication.

This study was undertaken to clarify the status of the ACTH and cortisol responses to CRH in patients with white coat hypertension.

White coat hypertension was defined as a difference between clinic blood pressure and ambulatory blood pressure of at least 20 mm Hg for systolic blood pressure and/or 10 mm Hg for diastolic blood pressure.

Who Took Part

The abstract describes 1700 patients taking part.

By PubMed's age tags, the people studied were adults and middle-aged adults, both men and women.

How the Study Was Run

Blood pressure and heart rate were measured 15 min before, at time zero, and 15, 30, 60, and 120 min after initiation of the CRH stimulation tests.

What Was Measured

CRH stimulation tests were performed between 1400 and 1700 h in 11 patients with white coat hypertension (4 males and 7 females) and 11 normal subjects (4 males and 7 females).

PubMed files the paper under topics including Adrenocorticotropic Hormone, Blood Pressure Determination, Corticotropin-Releasing Hormone, Hydrocortisone, Hypertension, Hypothalamo-Hypophyseal System and Pituitary-Adrenal System.

What This Means in Plain Language

This is a controlled clinical trial of ACTH (Corticotropin) and CRH (Corticotropin-Releasing Hormone) in 1700 patients.

With several hundred people or more, it is a fairly large study for this kind of research.

The publication is from 2002 (The Journal of clinical endocrinology and metabolism), a journal based in United States.

More context: the ACTH (Corticotropin) compound page and the CRH (Corticotropin-Releasing Hormone) compound page, all human trials.