Accelerated escape from GH autonegative feedback in midpuberty in males: evidence for time-delimited GH-induced somatostatinergic outflow in adolescent boys.

What Was Tested

This randomized controlled trial looks at Human Growth Hormone.

A single injected pulse of GH inhibits the time-delayed secretion of GH in the adult by way of central mechanisms that drive somatostatin and repress GHRH outflow.

The marked amplification of spontaneous GH pulse amplitude in puberty poses an autoregulatory paradox.

Who Took Part

The study group was 18 subjects.

PubMed indexes the participants as children and teenagers, men only.

How the Study Was Run

The design is described as randomized.

The subjects were allocated by chance, so the Human Growth Hormone group and the comparison group should start out alike.

What Was Measured

The subject headings attached to it are Age Factors, Estradiol, Feedback, Physiological, Growth Hormone-Releasing Hormone, Homeostasis, Human Growth Hormone and Insulin-Like Growth Factor I.

What This Means in Plain Language

The paper is a randomized study of Human Growth Hormone in 18 subjects.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The publication is from 2002 (The Journal of clinical endocrinology and metabolism), a journal based in United States.

More context: the related Exogenous HGH, sermorelin & older GHRPs (why they're passed over) library page, all human trials.