Plasma cholecystokinin is associated with subjective measures of satiety in women

What Was Tested

Researchers studied Cholecystokinin (CCK) in this randomized controlled trial publication.

Visual analogue scales were used to assess subjects' hunger, desire to eat, fullness, and prospective consumption.

Why It Was Studied

Fat stimulates cholecystokinin release, and fiber appears to prolong cholecystokinin elevation during the alimentary period.

Who Took Part

The study group was 7 men.

PubMed indexes the participants as adults and middle-aged adults, both men and women.

Blood samples were drawn from fasted subjects (7 men and 8 women) before and at different time points after test meal consumption for 6 h.

How the Study Was Run

In design terms this was a randomized and crossover study.

Random assignment meant chance, not the researchers, decided who got Cholecystokinin (CCK) and who got the comparison, which limits bias.

Each person switched between Cholecystokinin (CCK) and the comparison at some point, usually with a gap in between.

Three isoenergetic breakfast meals were tested in a randomized crossover design: low fiber, low fat; high fiber, low fat; and low fiber, high fat.

Plasma was analyzed for cholecystokinin, insulin, glucose, and triacylglycerols.

What Was Measured

Topics PubMed links to this paper include Blood Glucose, Cholecystokinin, Diet Records, Dietary Fats, Dietary Fiber, Eating and Energy Intake.

What This Means in Plain Language

The paper is a randomized and crossover study of Cholecystokinin (CCK) in 7 men.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The abstract goes on to report its results in about 4 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2002 (The American journal of clinical nutrition), a journal based in United States.

More context: the Cholecystokinin (CCK) compound page, all human trials.