Effects of a fixed mixture of 25% insulin lispro and 75% NPL on plasma glucose during and after moderate physical exercise in patients with type 2 diabetes

What Was Tested

The paper reports a study of Insulin Lispro, published as a randomized controlled trial.

Who Took Part

By PubMed's age tags, the people studied were adults, middle-aged adults and older adults, both men and women.

Thirty-seven patients were treated in a randomized, open-label, 8-week, two-period crossover study.

Following the 4-week outpatient phase, patients were hospitalized, and exercised at a heart rate of 120 beats/min on a cycle ergometer two times for 30 min, separated by 30 min rest, starting 3 h after a 339 kcal breakfast.

How the Study Was Run

In design terms this was a randomized, open-label and crossover study.

Random assignment meant chance, not the researchers, decided who got Insulin Lispro and who got the comparison, which limits bias.

Everyone knew when Insulin Lispro was being given (open label), which is simpler to run but leaves more room for expectations to affect what is reported.

In the crossover set-up each of the participants took both Insulin Lispro and the comparison in turn, acting as their own control.

What Was Measured

PubMed files the paper under topics including Blood Glucose, Diabetes Mellitus, Type 2, Exercise, Hypoglycemic Agents, Insulin, Insulin Lispro and Linear Models.

What This Means in Plain Language

The paper is a randomized, open-label and crossover study of Insulin Lispro.

The abstract goes on to report its results in about 7 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2002 (Current medical research and opinion), a journal based in England.

More context: the Insulin Lispro compound page, all human trials.