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Efficacy and safety of highly purified menotropin versus recombinant follicle-stimulating hormone in in vitro fertilization/intracytoplasmic sperm injection cycles: a randomized, comparative trial
Plain-language guide to PMID 12215327 (2002): open-label randomized controlled trial study of HMG (Human Menopausal Gonadotropin) in 781 women.
Key Facts
- PMID
- 12215327
- Journal
- Fertility and sterility
- Year
- 2002
- Study type
- Randomized Controlled Trial
- Authors
- n/a
- DOI
- 10.1016/s0015-0282(02)03250-8
What This Study Did, in Plain Language
What Was Tested
Researchers studied HMG (Human Menopausal Gonadotropin) in this randomized controlled trial publication.
Who Took Part
The study group was 781 women.
The age groups tagged for this paper are adults, both men and women.
A total of 781 women were enrolled between May 1999 and November 2000.
In the all-patients-treated population, 373 patients received HP-hMG and 354 received recombinant FSH.
How the Study Was Run
The design is described as randomized, open-label and parallel-group.
The women were allocated by chance, so the HMG (Human Menopausal Gonadotropin) group and the comparison group should start out alike.
Nothing was hidden in this open-label HMG (Human Menopausal Gonadotropin) study: the women and staff both knew the treatment.
The HMG (Human Menopausal Gonadotropin) group and the comparison group ran side by side rather than switching.
Multinational, open label, randomized, parallel group, comparative phase III trial.
In 22 centers across six countries; Belgium (1 center), Germany (6 centers), Israel (6 centers), The Netherlands (2 centers), Switzerland (1 center) and the United Kingdom (6 centers).
A long protocol GnRH agonist regimen was used.
What Was Measured
PubMed files the paper under topics including Estradiol, Fertilization, Fertilization in Vitro, Follicle Stimulating Hormone, Infertility, Female, Infertility, Male and Melanocyte-Stimulating Hormones.
What This Means in Plain Language
The paper is a randomized, open-label and parallel-group study of HMG (Human Menopausal Gonadotropin) in 781 women.
With several hundred people or more, it is a fairly large study for this kind of research.
The abstract goes on to report its results in about 6 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 2002 (Fertility and sterility), a journal based in United States.
More context: the HMG (Human Menopausal Gonadotropin) compound page, all human trials.
Our Notes on the Compound
HMG (Human Menopausal Gonadotropin): Menotropins: a glycoprotein preparation that supplies follicle-stimulating hormone (FSH) and luteinizing hormone (LH) activity.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.