← Human Trials & Peer-Reviewed Studies
Plasma brain natriuretic peptide concentration: impact of age and gender
Plain-language guide to PMID 12225726 (2002): randomized controlled trial of BNP (Nesiritide).
Key Facts
- PMID
- 12225726
- Journal
- Journal of the American College of Cardiology
- Year
- 2002
- Study type
- Randomized Controlled Trial
- Authors
- Redfield MM et al. (6 authors)
- DOI
- 10.1016/s0735-1097(02)02059-4
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial looks at BNP (Nesiritide).
The researchers wished to examine the effects of age and gender on plasma brain natriuretic peptide (BNP) concentration in a population-based study.
Why It Was Studied
Measurement of BNP concentration is approved for use in the diagnosis of heart failure and may aid in the detection of left ventricular dysfunction.
Although BNP is approved for clinical use, there are few data regarding the range of BNP observed in persons without cardiovascular disease or cardiac dysfunction.
Who Took Part
The age groups tagged for this paper are middle-aged adults, older adults and people over 80, both men and women.
A normal subset of subjects (n = 767) in sinus rhythm without cardiovascular, renal, or pulmonary disease or diabetes; on no cardiovascular medications; and with normal systolic, diastolic, and valvular function was identified.
How the Study Was Run
In design terms this was a randomized study.
Because people in this BNP (Nesiritide) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
In 2,042 randomly selected residents of Olmsted County, Minnesota, >44 years old, BNP (Shionogi and Biosite assays), Doppler echocardiography, and medical record review were performed.
What Was Measured
Measurement of BNP concentration is approved for use in the diagnosis of heart failure and may aid in the detection of left ventricular dysfunction.
The subject headings attached to it are Age Factors, Natriuretic Peptide, Brain, ROC Curve and Sex Factors.
What This Means in Plain Language
The paper is a randomized study of BNP (Nesiritide).
Results are reported in around 4 sentences of the abstract; we leave them to the paper itself rather than summarise them.
The publication is from 2002 (Journal of the American College of Cardiology), a journal based in United States.
More context: the BNP (Nesiritide) compound page, all human trials.
Our Notes on the Compound
BNP (Nesiritide): B-type natriuretic peptide, a 32-amino-acid heart hormone; nesiritide (Natrecor) is a recombinant form used in acute heart failure.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.