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Influence of AT1 receptor blockade on blood pressure, renal haemodynamics and hormonal responses to intravenous angiotensin II infusion in hypertensive patients
Plain-language guide to PMID 12361194 (2002): double-blind randomized controlled trial study of Angiotensin II in 24 patients, low blood pressure and orthostatic hypotension.
Key Facts
- PMID
- 12361194
- Journal
- Blood pressure
- Year
- 2002
- Study type
- Randomized Controlled Trial
- Authors
- Fridman KU et al. (5 authors)
- DOI
- 10.1080/08037050213766
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Angiotensin II in the context of low blood pressure and orthostatic hypotension, published as a randomized controlled trial.
The aim of this study was to investigate blood pressure, renal haemodynamics, hormone secretion and the responses to angiotensin II infusion during candesartan cilexetil (candesartan), losartan potassium (losartan) and valsartan treatment in patients with essential hypertension.
Who Took Part
The study group was 24 patients.
By PubMed's age tags, the people studied were adults, middle-aged adults and older adults, both men and women.
How the Study Was Run
In design terms this was a randomized, double-blind, placebo-controlled and crossover study.
Random assignment meant chance, not the researchers, decided who got Angiotensin II and who got the comparison, which limits bias.
Blinding on both sides kept the patients and researchers unaware of who received Angiotensin II.
Some patients received a placebo instead of Angiotensin II, giving a reference point.
Each person switched between Angiotensin II and the comparison at some point, usually with a gap in between.
Before infusion and at the end of each infusion step, blood pressure and renal haemodynamics were assessed and plasma renin activity and plasma concentrations of angiotensin II and aldosterone were measured.
What Was Measured
Topics PubMed links to this paper include Aldosterone, Angiotensin II, Angiotensin Receptor Antagonists, Benzimidazoles, Biphenyl Compounds, Blood Pressure and Hemodynamics.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Angiotensin II in 24 patients in people with low blood pressure and orthostatic hypotension.
With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.
The publication is from 2002 (Blood pressure), a journal based in England.
More context: the Angiotensin II compound page, Low blood pressure and orthostatic hypotension research.
Our Notes on the Compound
Angiotensin II: An 8-amino-acid hormone that narrows blood vessels; synthetic angiotensin II (Giapreza) is used for low blood pressure in shock.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.