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Estimation of the effect of the acute phase response on indicators of micronutrient status in Indonesian infants.
Plain-language guide to PMID 12368396 (2002): double-blind randomized controlled trial of Zinc and beta Carotene in 418 infants.
Key Facts
- PMID
- 12368396
- Journal
- The Journal of nutrition
- Year
- 2002
- Study type
- Randomized Controlled Trial
- Authors
- Wieringa FT et al. (5 authors)
- DOI
- 10.1093/jn/131.10.3061
What This Study Did, in Plain Language
What Was Tested
Researchers studied Zinc and beta Carotene in this randomized controlled trial publication.
Many indicators of micronutrient status change during infection because of the acute phase response.
In this study, relationships between the acute phase response, assessed by measuring concentrations of C-reactive protein (CRP), alpha(1)-antichymotrypsin (ACT) and alpha(1)-acid glycoprotein (AGP), and indicators of micronutrient status were analyzed in 418 infants who completed a 6-mo randomized, double-blind, placebo-controlled, supplementation trial with iron, zinc and/or beta-carotene.
Who Took Part
The abstract describes 418 infants taking part.
The age groups tagged for this paper are infants, both men and women.
How the Study Was Run
The researchers set it up as a randomized, double-blind and placebo-controlled study.
The infants were allocated by chance, so the Zinc group and the comparison group should start out alike.
As a double-blind Zinc study, the assignments were hidden from both participants and investigators until the end.
Some infants received a placebo instead of Zinc, giving a reference point.
What Was Measured
In this study, relationships between the acute phase response, assessed by measuring concentrations of C-reactive protein (CRP), alpha(1)-antichymotrypsin (ACT) and alpha(1)-acid glycoprotein (AGP), and indicators of micronutrient status were analyzed in 418 infants who completed a 6-mo randomized, double-blind, placebo-controlled, supplementation trial with iron, zinc and/or beta-carotene.
The subject headings attached to it are Acute-Phase Proteins, Acute-Phase Reaction, Anemia, Iron-Deficiency, Biomarkers, C-Reactive Protein, Dietary Supplements and Ferritins.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Zinc and beta Carotene in 418 infants.
With several hundred people or more, it is a fairly large study for this kind of research.
The publication is from 2002 (The Journal of nutrition), a journal based in United States.
More context: the related Vitamin D, K2, Magnesium and Zinc library page, all human trials.
Related Library Page
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.