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The effect of growth hormone on the development of in vitro matured unstimulated human oocytes.

Plain-language guide to PMID 12403212 (2002): randomized controlled trial of Exogenous HGH, sermorelin & older GHRPs (why they're passed over) in 47 patients.

Key Facts

PMID
12403212
Journal
Journal of the Medical Association of Thailand = Chotmaihet thangphaet
Year
2002
Study type
Randomized Controlled Trial
Authors
Sophonsritsuk A et al. (9 authors)

What This Study Did, in Plain Language

What Was Tested

This randomized controlled trial looks at Exogenous HGH, sermorelin & older GHRPs (why they're passed over).

To investigate the effect of growth hormone on the development of in vitro matured unstimulated human oocytes.

Who Took Part

The study group was 47 patients.

PubMed tags the participants as women only.

Division of Reproductive Medicine, Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn university.

108 germinal vesicle-stage oocytes were retrieved from 47 patients undergoing gynecologic surgery.

How the Study Was Run

The design is described as randomized.

Because people in this Exogenous HGH, sermorelin & older GHRPs (why they're passed over) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

They were aspirated either during gynecologic surgery or from excised ovaries.

The oocytes were then cultured in vitro with or without growth hormone (1,000 ng/ml) in medium199 supplemented with sodium pyruvate, FSH, LH, antibiotic and synthetic serum.

Incubation was done at 37 degree C with 5 per cent CO2 in air and nuclear stage was assessed after 18, 42, 66 and 90 h of incubation.

What Was Measured

PubMed files the paper under topics including Chi-Square Distribution, Growth Hormone, In Vitro Techniques, Metaphase, Oocytes and Thailand.

What This Means in Plain Language

The paper is a randomized study of Exogenous HGH, sermorelin & older GHRPs (why they're passed over) in 47 patients.

Results are reported in around 3 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2002 (Journal of the Medical Association of Thailand = Chotmaihet thangphaet), a journal based in Thailand.

More context: the Exogenous HGH, sermorelin & older GHRPs (why they're passed over) compound page, all human trials.

Our Notes on the Compound

Exogenous HGH, sermorelin & older GHRPs (why they're passed over): Constant levels suppress the body's own GHRH, raise somatostatin and dull pituitary response.

Related Pages

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.