Angiotensin II type 1 receptor polymorphisms in the cardiovascular health study: relation to blood pressure, ethnicity, and cardiovascular events.

What Was Tested

This randomized controlled trial looks at the intervention named in the title in the context of low blood pressure and orthostatic hypotension.

The researchers examined the association between this polymorphism and new-onset hypertension, blood pressure (BP) control, and incident cardiovascular events in a large population-based cohort of older adults.

Who Took Part

According to the abstract, 1,371 participants were involved.

PubMed indexes the participants as older adults, both men and women.

Eight hundred self-identified African Americans and 1,371 randomly selected white participants in the Cardiovascular Health Study were genotyped.

How the Study Was Run

The researchers set it up as a randomized study.

Random assignment meant chance, not the researchers, decided who got the intervention named in the title and who got the comparison, which limits bias.

The median duration of follow-up was 8.1 years.

What Was Measured

The subject headings attached to it are Black People, Blood Pressure, Cardiovascular Diseases, Gene Frequency, Hypertension, Polymorphism, Genetic and Receptor, Angiotensin, Type 1.

What This Means in Plain Language

The paper is a randomized study in 1,371 participants in people with low blood pressure and orthostatic hypotension.

With several hundred people or more, it is a fairly large study for this kind of research.

The abstract goes on to report its results in about 6 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2002 (American journal of hypertension), a journal based in United States.

More context: Low blood pressure and orthostatic hypotension research.