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Secretin and sleep in children with autism
Plain-language guide to PMID 12462350 (2002): double-blind randomized controlled trial study of Secretin.
Key Facts
- PMID
- 12462350
- Journal
- Child psychiatry and human development
- Year
- 2002
- Study type
- Randomized Controlled Trial
- Authors
- Honomichl RD et al. (5 authors)
- DOI
- 10.1023/a:1020778108068
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Secretin, published as a randomized controlled trial.
The objectives of this pilot study were 1) to examine possible effects of secretin infusions on sleep-wake state organization in children with autism, and 2) to assess the feasibility of home recordings using time-lapse videosomnography in children with autism.
Why It Was Studied
Participants were a subset of subjects from two double blind, placebo-control, multi-center clinical trials.
One trial, the UC Irvine study, assessed the effects of porcine secretin vs. saline infusions on children's behavior, language and IQ.
Who Took Part
PubMed indexes the participants as young children and children.
How the Study Was Run
The design is described as randomized, double-blind, placebo-controlled, crossover and pilot.
Random assignment meant chance, not the researchers, decided who got Secretin and who got the comparison, which limits bias.
Neither the participants nor the staff measuring them knew who was on Secretin, so expectations could not easily colour the readings.
Some participants received a placebo instead of Secretin, giving a reference point.
In the crossover set-up each of the participants took both Secretin and the comparison in turn, acting as their own control.
What Was Measured
One trial, the UC Irvine study, assessed the effects of porcine secretin vs. saline infusions on children's behavior, language and IQ.
The UC Davis trial assessed the effects of synthetic human secretin vs. saline infusions on behavior, language and gastrointestinal function.
PubMed files the paper under topics including Autistic Disorder, Gastrointestinal Agents, Multivariate Analysis, Pilot Projects, Polysomnography, Secretin and Sleep Wake Disorders.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Secretin.
The publication is from 2002 (Child psychiatry and human development), a journal based in United States.
More context: the Secretin compound page, all human trials.
Our Notes on the Compound
Secretin: A 27-amino-acid gut hormone that triggers pancreatic secretion; used as a diagnostic agent in pancreatic function testing.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.