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Growth hormone-releasing hormone facilitates hypoglycemia-induced release of cortisol
Plain-language guide to PMID 12468113 (2002): controlled clinical trial of GHRH (Growth Hormone-Releasing Hormone) and ACTH (Corticotropin) in 10 men.
Key Facts
- PMID
- 12468113
- Journal
- Regulatory peptides
- Year
- 2002
- Study type
- Controlled Clinical Trial
- Authors
- Perras B et al. (7 authors)
- DOI
- 10.1016/s0167-0115(02)00163-5
What This Study Did, in Plain Language
What Was Tested
This controlled clinical trial looks at GHRH (Growth Hormone-Releasing Hormone) and ACTH (Corticotropin).
For this purpose, pituitary-adrenal activity was stimulated in 10 men through a standard insulin-hypoglycemia-test (IHT) and in another 10 men through combined administration of CRH/vasopressin.
Why It Was Studied
Early sleep in humans is characterized by a distinct suppression of pituitary-adrenal activity coinciding with enhanced activity of the somatotropic axis.
Here, the researchers tested in awake humans the hypothesis of an inhibiting influence of hypothalamic growth hormone-releasing hormone (GHRH) on pituitary-adrenal activity.
Who Took Part
According to the abstract, 10 men were involved.
By PubMed's age tags, the people studied were adults, men only.
How the Study Was Run
The design is described as placebo-controlled.
The comparison arm used a placebo, so changes seen with GHRH (Growth Hormone-Releasing Hormone) could be set against what happens without it.
GH, ACTH and cortisol as well as blood pressure and heart rate were measured repeatedly.
What Was Measured
Here, the researchers tested in awake humans the hypothesis of an inhibiting influence of hypothalamic growth hormone-releasing hormone (GHRH) on pituitary-adrenal activity.
The subject headings attached to it are Adrenal Glands, Adrenocorticotropic Hormone, Affect, Blood Glucose, Blood Pressure, Corticotropin-Releasing Hormone and Growth Hormone-Releasing Hormone.
What This Means in Plain Language
The paper is a placebo-controlled study of GHRH (Growth Hormone-Releasing Hormone) and ACTH (Corticotropin) in 10 men.
With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.
The publication is from 2002 (Regulatory peptides), a journal based in Netherlands.
More context: the GHRH (Growth Hormone-Releasing Hormone) compound page and the ACTH (Corticotropin) compound page, all human trials.
Our Notes on the Compounds
GHRH (Growth Hormone-Releasing Hormone): The 44-amino-acid hypothalamic hormone that tells the pituitary to release growth hormone; sermorelin and tesamorelin are analogs.
ACTH (Corticotropin): The 39-amino-acid pituitary hormone that drives cortisol production; given as repository corticotropin (Acthar Gel).
CRH (Corticotropin-Releasing Hormone): The 41-amino-acid hypothalamic hormone that triggers ACTH release; corticorelin is used diagnostically.
Related Pages
- GHRH (Growth Hormone-Releasing Hormone) in the library
- ACTH (Corticotropin) in the library
- CRH (Corticotropin-Releasing Hormone) in the library
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.