Impact of bedtime snack composition on prevention of nocturnal hypoglycemia in adults with type 1 diabetes undergoing intensive insulin management using lispro insulin before meals: a randomized, placebo-controlled, crossover trial

What Was Tested

This randomized controlled trial paper looks at Insulin Lispro.

Who Took Part

According to the abstract, 15 adults were involved.

By PubMed's age tags, the people studied were adults, middle-aged adults and older adults, both men and women.

How the Study Was Run

The researchers set it up as a randomized, placebo-controlled and crossover study.

Random assignment meant chance, not the researchers, decided who got Insulin Lispro and who got the comparison, which limits bias.

The comparison arm used a placebo, so changes seen with Insulin Lispro could be set against what happens without it.

Each person switched between Insulin Lispro and the comparison at some point, usually with a gap in between.

All snacks were equivalent in kcal, fat, and total available glucose.

An intravenous facilitated hourly blood glucose sampling during the night (11:00 P.M. to 7:00 A.M.).

What Was Measured

The subject headings attached to it are Blood Glucose, Diabetes Mellitus, Type 1, Dietary Carbohydrates, Dietary Proteins, Eating, Hypoglycemia and Hypoglycemic Agents.

What This Means in Plain Language

The paper is a randomized, placebo-controlled and crossover study of Insulin Lispro in 15 adults.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

Its findings take up roughly 7 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2003 (Diabetes care), a journal based in United States.

More context: the Insulin Lispro compound page, all human trials.