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The role of zinc in the treatment of tinnitus.
Plain-language guide to PMID 12544035 (2003): randomized controlled trial of Zinc in 28 patients, tinnitus.
Key Facts
- PMID
- 12544035
- Journal
- Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
- Year
- 2003
- Study type
- Randomized Controlled Trial
- Authors
- Arda HN et al. (4 authors)
- DOI
- 10.1097/00129492-200301000-00018
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial looks at Zinc in the context of tinnitus.
This study was designed to investigate the role of zinc administration in treatment of tinnitus.
Who Took Part
The abstract describes 28 patients taking part.
By PubMed's age tags, the people studied were adults, middle-aged adults and older adults, both men and women.
Patients with tinnitus were admitted to the ear, nose, and throat clinic of the authors' hospital.
Patients with tinnitus with no know pathologic conditions of the ear, nose, and throat; the mean age of 28 patients receiving zinc was 51.2 years, and that of 13 patients given placebo was 55 years.
How the Study Was Run
The design is described as randomized and placebo-controlled.
Because people in this Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
A placebo (an inactive look-alike) gave the Zinc group a baseline to be compared against.
Blood zinc levels were measured.
Frequency was detected by audiometry, and loudness of tinnitus was screened by tinnitus match test.
A questionnaire that scored tinnitus subjectively between 0 and 7 was given to patients before zinc treatment.
What Was Measured
PubMed files the paper under topics including Auditory Threshold, Tinnitus and Zinc.
What This Means in Plain Language
The paper is a randomized and placebo-controlled study of Zinc in 28 patients in people with tinnitus.
With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.
Results are reported in around 8 sentences of the abstract; we leave them to the paper itself rather than summarise them.
The publication is from 2003 (Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology), a journal based in United States.
More context: the related Vitamin D, K2, Magnesium and Zinc library page, Tinnitus research.
Related Library Page
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.