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Gastrointestinal symptoms and blood indicators of copper load in apparently healthy adults undergoing controlled copper exposure
Plain-language guide to PMID 12600855 (2003): double-blind randomized controlled trial study of Copper (Supplement) in 1365 adults.
Key Facts
- PMID
- 12600855
- Journal
- The American journal of clinical nutrition
- Year
- 2003
- Study type
- Randomized Controlled Trial
- Authors
- Araya M et al. (6 authors)
- DOI
- 10.1093/ajcn/77.3.646
What This Study Did, in Plain Language
What Was Tested
Researchers studied Copper (Supplement) in this randomized controlled trial publication.
The objective was to assess acute gastrointestinal effects and blood markers of copper status in apparently healthy adults who underwent controlled copper exposure for 2 mo.
Why It Was Studied
Mild and moderate effects of marginally low and marginally high copper exposure are poorly understood in humans.
Who Took Part
The abstract describes 1365 adults taking part.
PubMed indexes the participants as adults and middle-aged adults, both men and women.
Blood markers were measured in 240 participants at the end of the survey.
Subjects with anemia, inflammation, or infection were excluded.
How the Study Was Run
In design terms this was a randomized and double-blind study.
Because people in this Copper (Supplement) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
Blinding on both sides kept the adults and researchers unaware of who received Copper (Supplement).
Serum and erythrocyte copper, peripheral mononuclear cell copper, serum ceruloplasmin, the nonceruloplasmin bound copper fraction, superoxide dismutase activity, hemoglobin, mean corpuscular volume, serum ferritin, and liver enzyme activities were measured.
What Was Measured
Topics PubMed links to this paper include Biomarkers, Ceruloplasmin, Copper, Digestive System, Drinking, Gastrointestinal Diseases and Homeostasis.
What This Means in Plain Language
The paper is a randomized and double-blind study of Copper (Supplement) in 1365 adults.
With several hundred people or more, it is a fairly large study for this kind of research.
Results are reported in around 7 sentences of the abstract; we leave them to the paper itself rather than summarise them.
The publication is from 2003 (The American journal of clinical nutrition), a journal based in United States.
More context: the Copper (Supplement) compound page, all human trials.
Our Notes on the Compound
Copper (Supplement): The active site of cytochrome c oxidase is described as containing copper ions that are essential for electron transfer.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.