Effect of calcium supplementation on blood pressure in patients with secondary hyperparathyroidism

What Was Tested

The paper reports a study of Parathyroid Hormone (PTH 1-84) in the context of hyperparathyroidism and low blood pressure and orthostatic hypotension, published as a randomized controlled trial.

The intervention study was a placebo-controlled, double-blind, cross-over, while the short study gave a placebo and calcium in random order on separate days.

The participants were obtained from an epidemiological survey in Tromsø 1994-1995 that included more than 27.000 subjects.

Who Took Part

The abstract describes 000 subjects taking part.

The age groups tagged for this paper are middle-aged adults, older adults and people over 80, both men and women.

How the Study Was Run

In design terms this was a randomized, double-blind, placebo-controlled and crossover study.

Because people in this Parathyroid Hormone (PTH 1-84) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

As a double-blind Parathyroid Hormone (PTH 1-84) study, the assignments were hidden from both participants and investigators until the end.

Some subjects received a placebo instead of Parathyroid Hormone (PTH 1-84), giving a reference point.

Each person switched between Parathyroid Hormone (PTH 1-84) and the comparison at some point, usually with a gap in between.

What Was Measured

There were 18 subjects with secondary hyperparathyroidism and 28 control subjects in the intervention study while there were 14 cases and 8 control subjects in the short study.

Topics PubMed links to this paper include Blood Pressure, Calcium, Hyperparathyroidism, Secondary and Parathyroid Hormone.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Parathyroid Hormone (PTH 1-84) in 000 subjects in people with hyperparathyroidism.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The publication is from 2003 (Journal of endocrinological investigation), a journal based in Italy.

More context: the Parathyroid Hormone (PTH 1-84) compound page, Hyperparathyroidism research, Low blood pressure and orthostatic hypotension research.