Effects of oral magnesium therapy on exercise tolerance, exercise-induced chest pain, and quality of life in patients with coronary artery disease.

What Was Tested

This randomized controlled trial looks at Magnesium.

However, the impact on clinical outcomes, such as exercise-induced chest pain, exercise tolerance, and quality of life, has not been established.

Symptom-limited exercise testing (Bruce protocol) and responses given on quality-of-life questionnaires were the outcomes measured.

Who Took Part

The abstract describes 187 patients taking part.

The age groups tagged for this paper are adults, middle-aged adults, older adults and people over 80, both men and women.

How the Study Was Run

In design terms this was a randomized, double-blind, placebo-controlled and multicenter study.

Random assignment meant chance, not the researchers, decided who got Magnesium and who got the comparison, which limits bias.

Blinding on both sides kept the patients and researchers unaware of who received Magnesium.

Some patients received a placebo instead of Magnesium, giving a reference point.

More than one site took part, so the patients came from several places.

What Was Measured

However, the impact on clinical outcomes, such as exercise-induced chest pain, exercise tolerance, and quality of life, has not been established.

Symptom-limited exercise testing (Bruce protocol) and responses given on quality-of-life questionnaires were the outcomes measured.

Topics PubMed links to this paper include Chest Pain, Coronary Disease, Dietary Supplements, Exercise Test, Exercise Tolerance, Magnesium and Probability.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Magnesium in 187 patients.

The publication is from 2003 (The American journal of cardiology), a journal based in United States.

More context: the related Vitamin D, K2, Magnesium and Zinc library page, all human trials.