Local and systemic tolerability of magnesium sulphate for tocolysis.

What Was Tested

Researchers studied Magnesium Sulfate in this randomized controlled trial publication.

The aim of this study was to examine the local and general tolerability and side-effects of magnesium sulphate for tocolysis.

Why It Was Studied

An open-label, randomised, parallel-group, study was conducted in three study centres in women with premature labor and indication for a single agent intravenous tocolysis therapy with magnesium sulphate.

Furthermore, the researchers tested the tolerability of a ready-for-use magnesium solution.

Who Took Part

By PubMed's age tags, the people studied were adults, women only.

Venous score (Maddox), vital signs, adverse events as well as general tolerability (assessed by investigator and patients) and blood parameters were assessed.

How the Study Was Run

The researchers set it up as a randomized, open-label and parallel-group study.

Random assignment meant chance, not the researchers, decided who got Magnesium Sulfate and who got the comparison, which limits bias.

Everyone knew when Magnesium Sulfate was being given (open label), which is simpler to run but leaves more room for expectations to affect what is reported.

Groups ran in parallel: each of the participants stayed in one arm throughout.

What Was Measured

Furthermore, the researchers tested the tolerability of a ready-for-use magnesium solution.

The subject headings attached to it are Blood Pressure, Magnesium, Magnesium Sulfate, Obstetric Labor, Premature and Tocolytic Agents.

What This Means in Plain Language

The paper is a randomized, open-label and parallel-group study of Magnesium Sulfate.

The publication is from 2003 (European journal of obstetrics, gynecology, and reproductive biology), a journal based in Ireland.

More context: all human trials.