Effects of valsartan with or without benazepril on blood pressure, angiotensin II, and endoxin in patients with essential hypertension

What Was Tested

This randomized controlled trial paper looks at Angiotensin II in the context of low blood pressure and orthostatic hypotension.

To evaluate the effects of valsartan (Val) with or without benazepril (Ben) on blood pressure and plasma levels of angiotensin (Ang II) and digoxin-immunoreactive factors (endoxin) in patients with essential hypertension.

Who Took Part

According to the abstract, 20 subjects were involved.

By PubMed's age tags, the people studied were adults and middle-aged adults, both men and women.

Age and sex-matched 20 normal subjects were served as control group.

How the Study Was Run

The design is described as randomized.

Because people in this Angiotensin II study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

What Was Measured

The subject headings attached to it are Angiotensin II, Angiotensin II Type 1 Receptor Blockers, Angiotensin-Converting Enzyme Inhibitors, Antihypertensive Agents, Benzazepines, Blood Pressure and Cardenolides.

What This Means in Plain Language

The paper is a randomized study of Angiotensin II in 20 subjects in people with low blood pressure and orthostatic hypotension.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The abstract goes on to report its results in about 8 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2003 (Acta pharmacologica Sinica), a journal based in United States.

More context: the Angiotensin II compound page, Low blood pressure and orthostatic hypotension research.