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The effect of zinc supplementation on linear growth, body composition, and growth factors in preterm infants.
Plain-language guide to PMID 12728080 (2003): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc and Copper (Supplement).
Key Facts
- PMID
- 12728080
- Journal
- Pediatrics
- Year
- 2003
- Study type
- Randomized Controlled Trial
- Authors
- Díaz-Gómez NM et al. (6 authors)
- DOI
- 10.1542/peds.111.5.1002
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc and Copper (Supplement).
The aim of their study was to evaluate the effect of zinc supplementation on linear growth, body composition, and growth factors in premature infants.
Who Took Part
The age groups tagged for this paper are infants, both men and women.
How the Study Was Run
The researchers set it up as a randomized, double-blind and placebo-controlled study.
The participants were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.
Neither the participants nor the staff measuring them knew who was on Vitamin D, K2, Magnesium and Zinc, so expectations could not easily colour the readings.
A placebo (an inactive look-alike) gave the Vitamin D, K2, Magnesium and Zinc group a baseline to be compared against.
At each evaluation, anthropometric variables and bioelectrical impedance were measured, a 3-day dietary record was collected, and a blood sample was taken.
The researchers analyzed serum levels of total alkaline phosphatase, skeletal alkaline phosphatase (sALP), insulin growth factor (IGF)-I, IGF binding protein-3, IGF binding protein-1, zinc and copper, and the concentrations of zinc in erythrocytes.
What Was Measured
Topics PubMed links to this paper include Alkaline Phosphatase, Anthropometry, Body Composition, Copper Sulfate, Dietary Proteins, Dietary Supplements and Electric Impedance.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc and Copper (Supplement).
Its findings take up roughly 4 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.
The publication is from 2003 (Pediatrics), a journal based in United States.
More context: the Vitamin D, K2, Magnesium and Zinc compound page and the Copper (Supplement) compound page, all human trials.
Our Notes on the Compounds
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Copper (Supplement): The active site of cytochrome c oxidase is described as containing copper ions that are essential for electron transfer.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.