Body Weight-Related ionized hypomagnesemia in pediatric patients undergoing cardiopulmonary bypass for surgical repair of congenital cardiac defects.

What Was Tested

This randomized controlled trial looks at Magnesium.

To examine the serial time course of perioperative plasma ionized magnesium (iMg(2+)) concentrations and to analyze the plasma iMg(2+) concentrations in children with different body mass who were undergoing open-heart surgery.

Who Took Part

According to the abstract, 38 children were involved.

By PubMed's age tags, the people studied were young children, both men and women.

38 children undergoing open-heart surgery.

Patients were divided into three groups according to their body mass: Group 1 (n = 12) <10 kg, Group 2 (n = 13) 10 kg to 20 kg, and Group 3 (n = 13) >20 kg.

How the Study Was Run

The researchers set it up as a randomized and single-blind study.

Because people in this Magnesium study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Only one side, usually the children, was kept unaware of whether Magnesium was given.

University-affiliated hospital of an academic medical institution.

The relationship of iMg(2+) among the three groups of different body mass were analyzed at five different time intervals during the operation: induction of anesthesia, 5 minutes and 30 minutes after the onset of cardiopulmonary bypass (CPB), the beginning of rewarming, and the end of surgery.

What Was Measured

The subject headings attached to it are Cardiopulmonary Bypass, Heart Defects, Congenital, Magnesium and Magnesium Deficiency.

What This Means in Plain Language

The paper is a randomized and single-blind study of Magnesium in 38 children.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The abstract goes on to report its results in about 5 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2003 (Journal of clinical anesthesia), a journal based in United States.

More context: the related Vitamin D, K2, Magnesium and Zinc library page, all human trials.