Intestinal and systemic immune responses to an oral cholera toxoid B subunit whole-cell vaccine administered during zinc supplementation.

What Was Tested

The paper reports a study of Vitamin D, K2, Magnesium and Zinc in the context of immune system (general), published as a randomized controlled trial.

Zinc plays a critical role in the normal functioning of the immune system.

The researchers investigated whether zinc sulfate administered orally to adult zinc-replete volunteers modulates systemic and intestinal immune responses to an oral killed cholera toxoid B subunit (CTB) whole-cell cholera vaccine.

Who Took Part

According to the abstract, 30 participants were involved.

The age groups tagged for this paper are adults.

How the Study Was Run

The researchers set it up as a randomized study.

Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.

What Was Measured

The researchers investigated whether zinc sulfate administered orally to adult zinc-replete volunteers modulates systemic and intestinal immune responses to an oral killed cholera toxoid B subunit (CTB) whole-cell cholera vaccine.

The subject headings attached to it are Antibodies, Bacterial, C-Reactive Protein, Cholera Toxin, Cholera Vaccines, Intestines, Toxoids and Vaccination.

What This Means in Plain Language

The paper is a randomized study of Vitamin D, K2, Magnesium and Zinc in 30 participants in people with immune system (general).

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The publication is from 2003 (Infection and immunity), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, Immune system (general) research.