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Prospective intervention trial of a screening protocol to identify fetal trisomy 18 using maternal serum alpha-fetoprotein, unconjugated oestriol, and human chorionic gonadotropin
Plain-language guide to PMID 1283634 (1992): clinical trial study of hCG (human chorionic gonadotropin) in 19,491 women.
Key Facts
- PMID
- 1283634
- Journal
- Prenatal diagnosis
- Year
- 1992
- Study type
- Clinical Trial
- Authors
- Palomaki GE et al. (6 authors)
- DOI
- 10.1002/pd.1970121112
What This Study Did, in Plain Language
What Was Tested
This clinical trial paper looks at hCG (human chorionic gonadotropin).
Two prenatal centres in New England, routinely using a screening protocol for fetal Down syndrome that included maternal serum alpha-fetoprotein (AFP), unconjugated oestriol (uE3), and human chorionic gonadotropin (hCG) measurements in combination with maternal age, adopted a separate screening protocol for trisomy 18.
That protocol identified a pregnancy as being at high risk when AFP, uE3, and hCG measurements all fell at or below specified cut-offs (0.75, 0.60, and 0.55 multiples of the median, respectively), regardless of maternal age.
Who Took Part
The abstract describes 19,491 women taking part.
By PubMed's age tags, the people studied were adults, women only.
What Was Measured
Two prenatal centres in New England, routinely using a screening protocol for fetal Down syndrome that included maternal serum alpha-fetoprotein (AFP), unconjugated oestriol (uE3), and human chorionic gonadotropin (hCG) measurements in combination with maternal age, adopted a separate screening protocol for trisomy 18.
That protocol identified a pregnancy as being at high risk when AFP, uE3, and hCG measurements all fell at or below specified cut-offs (0.75, 0.60, and 0.55 multiples of the median, respectively), regardless of maternal age.
PubMed files the paper under topics including Chorionic Gonadotropin, Chromosome Aberrations, Chromosome Disorders, Chromosomes, Human, Pair 18, Estriol, Genetic Testing and Trisomy.
What This Means in Plain Language
This is a clinical trial of hCG (human chorionic gonadotropin) in 19,491 women.
With several hundred people or more, it is a fairly large study for this kind of research.
The publication is from 1992 (Prenatal diagnosis), a journal based in England.
More context: the hCG (human chorionic gonadotropin) compound page, all human trials.
Our Notes on the Compound
hCG (human chorionic gonadotropin): An LH analog that drives Leydig-cell testosterone production.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.