The effect of a single oral morning dose of nizatidine and ranitidine on intragastric pH under basal conditions and after pentagastrin stimulation

What Was Tested

This randomized controlled trial paper looks at Pentagastrin.

A comparison was made of the antisecretory activity of orally administered nizatidine and ranitidine by measuring intragastric pH under basal conditions and during and after pentagastrin stimulation.

The antisecretory activity of the two drugs was similar during the 4 h of monitoring following drug administration.

Who Took Part

According to the abstract, 10 patients were involved.

The age groups tagged for this paper are adults and middle-aged adults, both men and women.

Intragastric pH values were measured with a bipolar glass electrode in 10 patients with healed duodenal ulcers treated with nizatidine or ranitidine according to a randomized single-blind design.

How the Study Was Run

The researchers set it up as a randomized and single-blind study.

Random assignment meant chance, not the researchers, decided who got Pentagastrin and who got the comparison, which limits bias.

Only one side, usually the patients, was kept unaware of whether Pentagastrin was given.

What Was Measured

A comparison was made of the antisecretory activity of orally administered nizatidine and ranitidine by measuring intragastric pH under basal conditions and during and after pentagastrin stimulation.

PubMed files the paper under topics including Gastric Acid, Gastric Acidity Determination, Nizatidine, Pentagastrin, Ranitidine and Stomach.

What This Means in Plain Language

The paper is a randomized and single-blind study of Pentagastrin in 10 patients.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The publication is from 1992 (The Journal of international medical research), a journal based in England.

More context: the Pentagastrin compound page, all human trials.