Magnesium-flush infusion into the aortic root just before reperfusion reduces the requirement for internal defibrillation and early post-perfusion arrhythmias.

What Was Tested

The paper reports a study of Magnesium, published as a randomized controlled trial.

The aim of this randomized, double-blind study was to compare the effects of intra-operative magnesium or placebo on intra-operative arrhythmias in patients undergoing coronary bypass grafting.

Why It Was Studied

Patients received a flush infusion of magnesium or placebo into the aortic root before cross-clamp removal.

Who Took Part

The age groups tagged for this paper are middle-aged adults and older adults, both men and women.

How the Study Was Run

In design terms this was a randomized, double-blind, placebo-controlled and multicenter study.

Because people in this Magnesium study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Blinding on both sides kept the participants and researchers unaware of who received Magnesium.

The comparison arm used a placebo, so changes seen with Magnesium could be set against what happens without it.

Running at several centres spread the Magnesium study over different clinics and patient groups.

What Was Measured

Topics PubMed links to this paper include Aorta, Arrhythmias, Cardiac, Cardiopulmonary Bypass, Electric Countershock, Magnesium, Myocardial Reperfusion Injury and Postoperative Complications.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Magnesium.

The publication is from 2004 (The Journal of international medical research), a journal based in England.

More context: the related Vitamin D, K2, Magnesium and Zinc library page, all human trials.